Recently reported was the effects of 150 milligrams of resveratrol per day given to obese men for 30 days. These effects were measured on the adipose tissue (fat cells) of those men given resveratrol. The aim of the study was to gain more insight into the effects of 30 days resveratrol supplementation to understand its effects on the behavior and processes that occur. The study involved eleven healthy obese men, who were supplemented with placebo and resveratrol for 30 days at a dose of 150 mg per day. This was separated by a 4-week washout period in a double-blind randomized crossover design.
Analysis of abdominal subcutaneous fat tissue was collected via biopsy to examine the changes. Resveratrol significantly decreased fat cell (adipocyte) size, with a shift toward a reduction in the proportion of large and very-large adipocytes and an increase in small adipocytes. Ultimately, it was revealed that resveratrol supplementation improves the breakdown of the fat cells and size reduction. Do note that resveratrol works primarily by a low-dose hormesis effect. This means that it works by activating liver enzymes, so high blood levels are not necessary to receive benefits from it. In addition, resveratrol works best in a synergy with other plant based polyphenols, particularly quercetin, curcumin and sulforaphane. All of these polyphenols can be found in a formula called Antioxidant Boost.
. Int J Obes (Lond). 2013 Aug 20. doi: 10.1038/ijo.2013.155.