The Effect of Tripeptide Copper Complex on Human Hair Growth

Sep 29, 2013
Hair Loss
1 0
Copper Tri-peptides

If you’ve been looking into ways to treat hair loss for a while, chances are you have at least heard of “copper peptides” for hair growth. Copper peptides are the mineral copper, bonded with three protein fragments (peptides). These peptides are the amino acids alanine, histidine and lysine. Better known as copper-AHK (Cu-AHK).

The primary mechanisms are many. Its effects on growth on many types of cells, such as boosting the number (proliferation) of fibroblasts, increasing the production of vascular endothelial growth factor (VEGF), which is a substance that allows the formation of new blood vessels. Copper peptides also reduces the secretion of transforming growth factor-beta1 within the fibroblasts. Reducing this secretion is crucial to void out the negative effects of DHT. [1]

The ultimate result is less oxidative stress (free-radical attack) and a stimulation of hair growth by the dermal papilla cells. It is oxidative stress that stimulates elevated DHT formation in scalp follicles. This copper complex inhibits oxidative stress by raising the production of SOD (Superoxide dismutase), which in turn neutralizes the potent free-radical superoxide.

The Other Copper Tripeptide (Cu-GHK)
The peptide Gly-His-Lys (GHK) is a naturally occurring copper found in human serum and cerebrospinal fluid. Copper-GHK plays a physiological role in the process of wound healing and tissue repair by stimulating collagen synthesis in fibroblasts. Moreover, copper-GHK promotes the survival of basal stem cells in the skin. [2] Several studies on aged skin have demonstrated that Cu-GHK tightens skin, improves elasticity and firmness, reduces fine lines, wrinkles, photo-damage and hyperpigmentation. [3]

[1]. Arch Pharm Res. 2007 Jul;30(7):834-9.
[2]. J Pept Sci. 2012 Nov;18(11):685-90.
[3]. J Biomater Sci Polym Ed. 2008;19(8):969-88.